This book originated from a series of papers which were published in “Die Naturwissenschaften” in Its division into three parts is the reflection of a . It is suggested that the concept of a hypercycle should be formally M. Eigen. Naturwissenschaften, 58 (), p. Eigen et al., “more RNA in replicators”. BOTH. FIRST more replicators: ecosystem based solution. Hypercycles (Eigen’s original solution). Emergence of higher levels of.

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Proceedings of the National Academy of Sciences.

Hypercycle (chemistry) – Wikipedia

Wicken the hypercycle theory is based on unwarranted assumptions about the conditions hypercyle prebiotic evolution and the implications of these assumptions run counter to both empirical evidence and to the rational by which natural selection operates in evolution generally. According to the hypercycle theory, the first primitive polymerase emerged precisely from this population.

This can be a solution to the error threshold problem, which states that, hypercycl a system without ideal replicationan excess of mutation events would destroy the ability to carry information and prevent the creation of larger and fitter macromolecules.

Autoexcision and autocyclization of the ribosomal RNA intervening sequence of tetrahymena”. They must have the ability to replicate itself and produce enzymes, that means, have a metabolism. Moreover, Vaidya et al. When a model of replicating molecules was created, [1] [2] it was found that, for effective storage of informationmacromolecules on prebiotic Earth could not exceed a certain threshold length.

Nevertheless, in both alternative concepts, the system will not survive due to the internal eigeen among its constituents. Bulletin of Mathematical Biology. The extinction of the hypercycle then follows. Hypercycles are claimed as a possible evolutionary precursor to living cells.

Some genotypes could introduce cooperation by recognizing target sequences of the other ribozymes, promoting their covalent bindingwhile other selfish genotypes were only able to self-assemble.


Hypercycles are also subject to evolution and, as such, can undergo a selection process. Existence of more than one such RNA template could make translation possible. Even if none of the constituents of such a system is selectively favoured, which potentially allows coexistence of all of the coupled molecules, they are not able to coevolve and optimize their properties.

These results were also explained analytically by the ODE model and its analysis. Moreover, it was shown that compartmentalized hypercycles are more sensitive to the input of deleterious mutations than a simple package of competing genes.

This observation was the motivation for the formulation of the hypercycle theory. Computational and Mathematical Methods in Medicine. Sequences I have a limited chain length and carry the information necessary to build catalytic chains E. In theory, it is possible to incorporate into the hypercycle mutations that do not satisfy the second condition. Moreover, there is also a problem with adding new information into the system. Furthermore, each molecule is additionally a subject for self-replication.

Emergence of the Hypercycle”]. At the time of hypercycle theory formulation, two models for the origin of translation code were proposed by Crick and his collaborators. The theory of evolution and dynamical systems: A principle of natural self-organization.

Later on, Josef Hofbauer and Karl Sigmund [46] indicated that in reality, a hypercycle can maintain only fewer than five members. Finally, the membrane surface can work as a catalyst.

Despite the above-mentioned advantages, there are also potential problems connected to compartmentalized hypercycles.


They are a purely and rather simple mathematical model that lacks any detail. Unfortunately, in this case, rotation decelerates as the number of hypercycle members increases, meaning that selection tends toward decreasing the amount of information stored in the hypercycle. Schuster proposed the model of hypercycles [1], as a hypothetical stage of macromolecular evolution, which could follow quasispecies.

In such a manner, the cycle reinforces itself. They are entirely speculative[1] with no apparent real world basis. Hypercycles stable against parasites”. Evolution of a hypercycle ensues from the creation of new components by the mutation of its internal species.


After that, the whole individualized and compartmentalized hypercycle can behave like a simple self-replicating entity. In his principal work, Manfred Eigen stated that the E coded by the I chain can be a specific polymerase or an enhancer or a silencer of a more general polymerase acting in favour of formation of the successor of nucleotide chain I.

The hypercycle. A principle of natural self-organization. Part A: Emergence of the hypercycle.

In agreement with Eigen and Schuster’s principal analysis, they argued that systems with five or more species exhibit limited and unstable cyclic behaviour, because some species can die out due to stochastic events and break the positive feedback loop that sustains the hypercycle. They invented a stochastic corrector model [10] that assumed that replicative templates compete within compartments, and selective values of these compartments depend on the internal composition of templates.

Such a concept, apart from an increased information capacity, has another advantage. The Stochastic Corrector Model vs.

The coexistence of various non-enzymatically replicating sequences could help to maintain a sufficient diversity of RNA modules used later to build molecules with catalytic hyperctcle. This favours preservation of beneficial mutations, because it prevents them from spreading away. The proposed model consists of a number of nucleotide sequences I I stands for eigej and the same number of polypeptide chains E E stands for enzyme.

Secondly, it keeps the effect of mutations local, while at the same time affecting the whole compartment.